A movie favorite for many, Patrick Dempsey had reached the peak of his early career popularity. He showed a more serious side in the WWII-era drama In a Shallow Grave (1988), which presented a Cyrano de Bergerac-like storyline with Patrick Dempsey as the Christian de Neuvillette counterpart, but then he went straight back to familiar territory with the college-themed comedies Some Girls (1988) with Jennifer Connelly, Loverboy (1989), and Happy Together (1989/I). Stretching more in the 1990s, Patrick co-starred on stage in a 1991 production of "The Subject Was Roses" (playing the Martin Sheen film role) as the WWII soldier readjusting to civilian life with his parents (Dana Ivey and "Frasier" co-star John Mahoney). Films included the cross-country comedy-drama Coupe de Ville (1990), the action thriller Run (1991), Mobsters (1991), in which he made a stab at playing major Mafioso Meyer Lansky, Face the Music (1993) opposite "Brat Pack" femme Molly Ringwald, the title role in Bank Robber (1993), and the Mark Twain family-geared Ava's Magical Adventure (1998), co-directed by Patrick Dempsey and wife Rocky. The couple, however, divorced that same year. On TV Patrick played a young John Fitzgerald Kennedy in the mini-movie J.F.K.: Reckless Youth (1993) (TV), Pierre Arronax in the TV remake of 20,000 Leagues Under the Sea (1997/II) (TV), and Raskolnikov in a small screen version of Crime and Punishment (1998) (TV). The rest of the decade on film was less newsworthy with co-starring or featured movie roles in Hugo Pool (1997), Denial (1998/I), There's No Fish Food in Heaven (1998) (aka Life in the Fast Lane) and Me and Will (1999). It was TV that gave Patrick Dempsey a shot in the arm as he progressed into the new millennium. A recurring role as Will's closeted sportscaster amour in the hit sitcom "Will & Grace" (1998) presented Patrick in a more mature, wry and sexier fashion. Another recurring role in "Once and Again" (1999) earned him a dramatic Emmy nomination in 2001as Outstanding Guest Actor, and a third on "The Practice" (1997) was also extremely well-received. While the romantic comedy film Sweet Home Alabama (2002) opposite Reese Witherspoon really nailed the direction Dempsey was headed, the medical series "Grey's Anatomy" (2005), as neurosurgeon Dr. Derek Shepherd (aka "Dr. McDreamy"), gave distaff audiences the whole heartthrob package. The perfect vehicle to showcase his undeniable charisma and sharp talent for offbeat comedy, he is a two-time Golden Globe nominee and his popularity has absolutely skyrocketed. This reawakening has also swung the door open again on high-profile film offers, registering with the ladies once again in a number of light leading man parts, notably Enchanted (2007) and Made of Honor (2008). Off-camera, Dempsey married a second time in 1999, to make-up artist and Delux Beauty founder Jill Fink. The couple have three children: daughter, Tallulah Fyfe (born 2002), and twin sons Darby Galen and Sullivan Patrick (born 2007). An avid sports car racer (he has participated in the Indianapolis and Daytona Beach events), he showed off a more humanitarian side when he started the Patrick Dempsey Center for Cancer Hope and Healing in his hometown of Lewiston after his mother developed ovarian cancer. Befittingly, he has produced a sexy men's fragrance line by Avon called "Unscripted".