In 2009 the producer Carla Estrada offered her the antagonistic role in the telenovela Sortilegio; in this telenovela, she was given the role of "Maura Albarran" who is someone who is in love with "Alejandro Lombardo" who was played by William Levy (actor). Also in 2009, Ana Brenda was offered the role in participating in the Mexican hit series Mujeres Asesinas, where she showed her fans the type of character she is capable in becoming. In this episode she worked with other extremly good actresses such as Paty Navidad and as well as Galilea Montijo. In this same year she was offered to as well participate in another hit series Tiempo Final. In 2010 she gives life to "Aurora" in the remake of Teresa, where she played the best friend of the protagonist who is Angelique Boyer. In addition to participating in the musical Timbiriche el Musical where she played "Carol".